adipic acid hazards

Anyone can earn The available data do not meet the classification criteria for Respiratory Sensitization. European Respiratory Journal 36:4:962-963. Adipic acid is not a liquid. Do you own anything that is made out of nylon such as shirts or athletic wear? High Production Volume Information System, USEPA. just create an account. Although adipic acid itself doesn't find use as a therapeutic agent, it has still found use in the medicinal and pharmaceutical industries. Other release to the environment of this substance is likely to occur from: indoor use (e.g. Substances listed in the EINECS, ELINCS, or NLP inventories. The highest dose administered in one volunteer was 70 g over 10 days. ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment. the electronic edition of the Official Journal of the European Union. Linear Formula HOOC(CH 2) 4 COOH . /Contents 4 0 R>> The available data do not meet the classification criteria for Carcinogenicity. Adipic acid has a chemical structure that does not contain metals or metalloids and is, therefore, excluded from classification [HPR 7.12.1(1)]. The CAS number is the substance numerical identifier assigned by the Chemical Abstracts Service, a division of the American Chemical Society, to substances registered in the CAS registry database. The direct synthesis of adipic acid from cyclohexene and hydrogen peroxide by a continuous micro-flow process. produce tissue damage in the eye or vision loss that is irreversible or not fully reversible within 21 days. E-mail address: Please upgrade your Internet Explorer to a newer version. You will not receive a reply. FDABF-GRAS-310. Inhalation Route of Exposure: Two human studies have been reported in the secondary literature. Industrial chemists make nylon by taking adipic acid and reacting it with hexamethylene diamine. Where does nylon come from though and how do chemists use it to provide things and materials we depend on daily for our lives? This database contains: (1) the list of hazardous substances harmonized for classification and labeling in EU (i.e. InfoCards are generated automatically based on the data available at the time of generation. Heidelberger, C. et al (1983)  Cell transformation by chemical agents -- a review and analysis of the literature. Ever since nylon was introduced to the world back in the 1930s by the chemical manufacturer DuPont, it has found application in countless applications in everything from toothbrushes to parachute chords. Adipic acid finds use in the food industry as both a flavoring and gelling aid for things like Jello. Adipic acid ,CAS N°124-04-9, Radici Chimica S.p.A. Adipic acid, CAS N° 124-04-9 Radici Chimica Deutschland GmbH, C&L Inventory, Registration dossier, Other, TECHNYL 1239 FL BLACK, TECHNYL 2720ST BLACK, KOPLA KDK1040BK, KOPLA KDP 1000R, KOPLA KDG1030, KOPLA KDG1030 BK900RD, KOPA KN333G30BL, KOPA KN333HRBL. If no EU harmonised classification and labelling exists and the substance was not registered under REACH, information derived from classification and labelling (C&L) notifications to ECHA under CLP Regulation is displayed under this section. Hexanedioic acid; 1,4-Butanedicarboxylic acid; 1,6-Hexanedioic acid; Acide adipique; Adipate. EC number: 204-673-3 | CAS number: 124-04-9, The OECD/ICCA high production volume chemicals program discussed data on adipic acid during SIAM 18, April 2004. Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The International Agency for Research on Cancer (IARC) and The American Conference of Governmental Industrial Hygienists (ACGIH) have not classified Adipic acid as a carcinogen. All rights reserved. However, in the latter case, precautions must be taken to avoid the risk of ignition of the dust. 15 - 75 % of the adipic acid dose was found unchanged in the urine after oral administration of up to 7 g of adipic acid over up to 10 days to 7 volunteers. Workplace Signage: Annexes I and III, Directive 92/58/EEC, last amended by Directive 2014/27/EU, 5 March 2014, Registration, Evaluation, Authorisation and Restriction of Chemicals, Chemical Agents Directive and Carcinogens or Mutagens Directive, Plastic Materials and Articles Regulation, Safety and/or Health Signs at Work Directive, EC Inventory, Pre-Registration process, CAD - Chemical Agents Directive, Art. Although the hazards of adipic acid are generally mild, its nature as a skin irritant makes it something to avoid if possible. Breath was not analyzed in these studies (Mori 1918; Bernhard and Andreae 1937; Enders 1941). Hazard classification & labelling Hazard classification and labelling. PubChem Substance ID 57653836. The described Product category (i.e. More information about the EC Inventory can be found here. Adipic acid is a carboxylic acid COOH(CH 2) 4 COOH manufactured in high volumes mostly for the production of nylon-6,6 fibers. Release to the environment of this substance can occur from industrial use: manufacturing of the substance. This is unique source of information on the chemicals manufactured and imported in Europe. Adipic acid is not a liquid. * Explosives are excluded from the Hazardous Products Act and Regulations. The mean score calculated following gradings at 24, 48, and 72 h for the 3 rabbits was  3, 2, and 2/4 for corneal opacity and: 2, 1.3 and 2/2 for iritis. Please be aware there may be intermittent unavailability while work in ongoing. Particle size distribution (Granulometry), Solubility in organic solvents / fat solubility, Stability in organic solvents and identity of relevant degradation products, Storage stability and reactivity towards container material, Biodegradation in water and sediment: simulation tests, Additional information on environmental fate and behaviour, Short-term toxicity to aquatic invertebrates, Long-term toxicity to aquatic invertebrates, Toxicity to aquatic algae and cyanobacteria, Toxicity to aquatic plants other than algae, Endocrine disrupter testing in aquatic vertebrates – in vivo, Toxicity to soil macroorganisms except arthropods, Endocrine disrupter mammalian screening – in vivo (level 3), Direct observations: clinical cases, poisoning incidents and other, Exposure related observations in humans: other data, Additional physico-chemical properties of nanomaterials, Toxicokinetics, metabolism and distribution. Hazards of Adipic Acid. Adipic acid was considered not mutagenic in a battery of in vitro tests on bacterial as well as mammalian cells in the presence and absence of metabolic activation Footnote 7,Footnote 8,Footnote 6,Footnote 9,Footnote 10,Footnote 3. In a key study performed according to OECD TG 405 and in compliance with GLP, application of 100 mg of Adipic acid (>99.8%) into the conjunctival sac of the right eye of 3 rabbits caused severe irritation (based on study summary Footnote 3).

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